Efficiency analysis of commercial polymeric membranes for bone regeneration in rat cranial defects.

PURPOSE: To evaluate the in vivo efficiency of commercial polymeric membranes for guided bone regeneration. METHODS: Rat calvarial critical size defects was treated with LuminaCoat (LC), Surgitime PTFE (SP), GenDerm (GD), Pratix (PR), Techgraft (TG) or control (C-) and histomorphometric analysis determined the percentage of new bone, connective tissue and biomaterial at 1 or 3 months. Statistical analysis used ANOVA with Tukey's post-test for means at same experimental time and the paired Student's t test between the two periods, considering p < 0.05. RESULTS: New bone at 1 month was higher for SP, TG and C-, at 3 months there were no differences, and between 1 and 3 months PR had greater increase growthing. Connective tissue at 1 month was higher for C-, at 3 months for PR, TG and C-, and between 1 and 3 months C- had sharp decline. Biomaterial at 1 month was higher for LC, in 3 months for SP and TG, and between 1 and 3 months, LC, GD and TG had more decreasing mean. CONCLUSIONS: SP had greater osteopromotive capacity and limitation of connective ingrowth, but did not exhibit degradation. PR and TG had favorable osteopromotion, LC less connective tissue and GD more accelerated biodegradation.

Efficiency analysis of commercial polymeric membranes for bone regeneration in rat cranial defects

Purpose: To evaluate the in vivo efficiency of commercial polymeric membranes for guided bone regeneration. Methods: Rat calvarial critical size defects was treated with LuminaCoat (LC), Surgitime PTFE (SP), GenDerm (GD), Pratix (PR), Techgraft (TG) or control (C-) and histomorphometric analysis determined the percentage of new bone, connective tissue and biomaterial at 1 or 3 months. Statistical analysis used ANOVA with Tukey's post-test for means at same experimental time and the paired Student's t test between the two periods, considering p < 0.05. Results: New bone at 1 month was higher for SP, TG and C-, at 3 months there were no differences, and between 1 and 3 months PR had greater increase growthing. Connective tissue at 1 month was higher for C-, at 3 months for PR, TG and C-, and between 1 and 3 months C- had sharp decline. Biomaterial at 1 month was higher for LC, in 3 months for SP and TG, and between 1 and 3 months, LC, GD and TG had more decreasing mean. Conclusion: SP had greater osteopromotive capacity and limitation of connective ingrowth, but did not exhibit degradation. PR and TG had favorable osteopromotion, LC less connective tissue and GD more accelerated biodegradation.

Anti-Inflammatory Effectiveness of Oral Dexamethasone 4 mg on Mandibular Third Molar Surgeries: A Split-Mouth Randomized Clinical Trial.

PURPOSE: This study aimed to evaluate the anti-inflammatory effect of oral dexamethasone 4 mg in a single dose preemptively administered to reduce pain, swelling, and trismus following mandibular third molar surgeries. METHODS: A split-mouth randomized clinical trial was performed including 22 participants undergoing surgical removal of bilateral and symmetrically positioned third molars. A total of 44 teeth were allocated by simple randomization to either the test or nonintervention/control side. Oral dexamethasone 4 mg was administered on the test side an hour before the surgery. All of the participants were unaware of the medication studied, and only 1 surgeon, blinded to the medication intake, performed all of the procedures. Anti-inflammatory effect was evaluated using the clinical parameters of mouth opening, swelling, and rescue analgesic medication intake to control pain. The statistical analysis was blinded to the allocation groups, and a significance value P < .05 was adopted for all the tests. RESULTS: Dexamethasone reduced the mean of rescue analgesic medication intake by 5 times (P = .002). Facial swelling was lower on the test side by 72h postsurgery in comparison with the control side (P = .036). No significant difference in mouth opening was found between the groups. CONCLUSIONS: Preemptive use of oral dexamethasone 4 mg proved to be effective in controlling pain and reducing the need for rescue medication and had a beneficial effect in reducing swelling during a short postoperative period.

Intervenção cirúrgica de um canino incluso em sínfise mandibular: relato de caso / Surgical intervention of an unerupted canine in mandibular sinfisis: case report

Objetivo: relatar um caso de exodontia do dente 43, incluso, na região do mento, com o auxílio de um exame complementar eficaz e de baixo custo: radiografia lateral de mandíbula utilizando filme oclusal. Relato de caso: paciente do gênero masculino, 26 anos de idade, melanoderma e normossistêmico, buscou tratamento ortodôntico por motivos de apinhamento dental anterior e presença do dente 83 (canino inferior decíduo) não esfoliado. Para um planejamento cirúrgico correto, foi realizada a radiografia lateral do mento com filme oclusal, em que se constatou que o dente 43 encontrava-se por vestibular em relação aos dentes anteriores inferiores. Assim, o paciente foi submetido à cirurgia sob anestesia local, para exodontia do dente 43. Considerações finais: o tratamento para transmigração de caninos inferiores deve incluir minuciosos planejamentos clínico e radiográfico. O tratamento sugerido para a grande maioria dos casos é a remoção cirúrgica, devido à possibilidade de falhas dos outros meios de tratamento, ocasionando complicações posteriores. (AU)

Objective: this paper aims to describe and discuss a surgical removal of canine included in the chin region with the aid of an effective and low-cost complementary exam: lateral radiographic of the mandible using the occlusal film. Case report: a male patient, 26 years old, without systemic diseases sought orthodontic treatment due to anterior crowding and presence of an unerupted tooth 83. In order to perform a correct surgical planning, the lateral radiograph of the occlusal film was performed, where it was found that the tooth 43 was in vestibular position in relation to the lower anterior teeth. Thus, the patient underwent surgery under local anesthesia for tooth extraction. Final considerations: the treatment for transmigration of lower canines should include careful clinical and radiographic planning. The suggested treatment for the vast majority of cases is surgical removal due to the possibility of failure of the other means of treatment, causing subsequent complications. (AU)